03/19/2024
Research Article
SMARCAL1 ubiquitylation and replication fork stability
The E3 ubiquitin ligase RFDW3 regulates replication fork progression and stability, but how does it achieve this? Maïlyn Yates, Alexandre Maréchal and co-workers reveal that SMARCAL1 is a substrate of RFWD3 and that its ubiquitylation disengages it from RPA, thereby limiting its activity at stalled replication forks and preventing fork collapse.
Image credit: pbio.3002552
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